Sinefungin-DataSheet-MedChemExpress

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Sinefungin

5 mg10 mg

Caution: Product has not been fully validated for medical applications. For research use only. Tel: 609-228-6898 Fax: 609-228-5909 E-mail: [email protected] Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

因轉碼可能存在排版等問題,敬請諒解!以下文字僅供您參考:

Inhibitors ? Agonists ? Screening Libraries

Product Data Sheet

Sinefungin

Cat. No.: CAS No.: Molecular Formula: Molecular Weight: Target: Pathway: Storage:

HY-101938 58944-73-3 C??H??N?O? 381.39 Histone Methyltransferase Epigenetics Please store the product under the recommended conditions in the COA.

SOLVENT & SOLUBILITY

In Vitro

H2O : 100 mg/mL (262.20 mM; Need ultrasonic)

Preparing Stock Solutions

Mass Solvent Concentration 1 mM

5 mM

1 mg 2.6220 mL 0.5244 mL

10 mM

0.2622 mL

Please refer to the solubility information to select the appropriate solvent.

5 mg

13.1099 mL 2.6220 mL 1.3110 mL

10 mg

26.2199 mL 5.2440 mL 2.6220 mL

BIOLOGICAL ACTIVITY

Description

Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation [2].

REFERENCES

[1]. Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7. [2]. Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.

McePdfHeight

1

www.MedChemExpress.com

Caution: Product has not been fully validated for medical applications. For research use only.

Tel: 609-228-6898

Fax: 609-228-5909

E-mail: [email protected]

Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

2

www.MedChemExpress.com

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  • www.vqhnth.tw true http://www.vqhnth.tw/wendangku/z2s/f2fg/j44651b8662v/kcaaedd3383c4bb4cf7ec4bfeb63bl.html report 1996 Sinefungin5 mg10 mgCaution: Product has not been fully validated for medical applications. For research use only. Tel: 609-228-6898Fax: 609-228-5909E-mail: [email protected] Address: 1 Deer Park Dr, Suite Q, Monmouth Ju
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