VDR-agonist-1-DataSheet-MedChemExpress

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VDR agonist 1Cat. No.:

HY-114310Molecular Formula:

C??H??N?O?Molecular Weight:

509.77Target:

VD/VDR Pathway:

Vitamin D Related Storage:Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITY

Description VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC 50 of 690 nM in MCF-7

cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by

increasing the expression of BAX and decrease the expression of Bcl-2[1].

IC?? & Target IC50: 690 nM (VDR in MCF-7 cells)[1].

REFERENCES

[1]. Wang C, et al. Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer. Eur J Med Chem. 2019 Feb 1;163:787-803.

McePdfHeight

Caution: Product has not been fully validated for medical applications. For research use only.

Tel: 609-228-6898 Fax: 609-228-5909 E-mail: [email protected]

Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

Product Data Sheet

Inhibitors ?Agonists ?Screening Libraries

www.MedChemExpress.com 1

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  • www.vqhnth.tw true http://www.vqhnth.tw/wendangku/z0s/f0ag/j2564f75712v/k52d380eb6294dd88d0d232d43c3bl.html report 1171 VDR agonist 1Cat. No.:HY-114310Molecular Formula:C??H??N?O?Molecular Weight:509.77Target:VD/VDR Pathway:Vitamin D Related Storage:Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITYDescrip
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