VDR agonist 1Cat. No.:
Vitamin D Related Storage:Please store the product under the recommended conditions in the COA.BIOLOGICAL ACTIVITY
Description VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC 50 of 690 nM in MCF-7
cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by
increasing the expression of BAX and decrease the expression of Bcl-2.
IC?? & Target IC50: 690 nM (VDR in MCF-7 cells).
. Wang C, et al. Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer. Eur J Med Chem. 2019 Feb 1;163:787-803.
Caution: Product has not been fully validated for medical applications. For research use only.
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Product Data Sheet
Inhibitors ?Agonists ?Screening Libraries